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Mekeel KL, Tang W, Kachnic LA, Luo CM, DeFrank JS, Powell SN (1997) Inactivation ofp53 results in high rates of homologous recombination. Thisresidue is within the major site for MDM2 attachment  and as a result of itsphosphorylation buy Pregabalin india p53-MDM2 interaction is disrupted leading to p53 stabilization.This cascade culminates in the G1 phase checkpoint wherein activated p53 inducesthe expression of its direct transcriptional target, p21, causing cell cycle arrest.